(2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-butanol-1

Name	(R)-CR8
Synonyms	R8 (S)-CR8 (R)-CR8 (R)-CR8 CR8, (R)-Isomer 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurinetrihydrochloride (2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-butanol-1 (2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol 1-Butanol,2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]Methyl]aMino]-9H-purin-2-yl]aMino]-,(2R)-
CAS	294646-77-8

Molecular Formula	C24H29N7O
Molar Mass	431.53
Melting Point	98-100℃
Solubility	Soluble in DMSO, not in water
Appearance	powder
Color	off-white
Storage Condition	2-8°C
Stability	Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Use	(R) - CR8 (CR8) is a second-generation analog of Roscovitine and is an effective CDK1/2/5/7/9 inhibitor. (R) - CR8 (CR8) inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R) - CR8 (CR8) induces apoptosis and has neuroprotective effect.

Last Update：2024-01-02 23:10:35

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CAS: 294646-77-8
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Mobile: 18021002903
QQ: 3008007409

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(2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-butanol-1 Request for Quotation